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Arsenic compounds are crucial drugs that have been utilised in both People’s Republic of China and also the Western globe for additional than 2,000 years. Arsenic trioxide (As2O3) and arsenic sulfide (As4S4) had been discovered to possess outstanding anti-leukemic activity specially against acute promyelocytic leukemia (APL).1? As2O3 has a synergistic effect when combined with all-trans-retinoic acid (ATRA). The precise mechanism of such synergistic effect on APL remains incompletely understood, though it was discovered that thei.
