Hidoni R, Sacchi N: Disruption of retinoic acid receptor alpha reveals the growth promoter face of retinoic acid. PLoS One 2007, 2:e836.23. Sussan TE, Pletcher MT, Murakami Y, Reeves RH: Tumor suppressor in lung cancer 1 (TSLC1) alters Define Inhibitors MedChemExpress tumorigenic growth properties and gene expression. Mol Cancer 2005, 4:28. 24. Vinodhkumar R, Song YS, Ravikumar V, Ramakrishnan G, Devaki T: Depsipeptide a histone deacetlyase inhibitor down regulates levels of matrix metalloproteinases 2 and 9 mRNA and protein expressions in lung cancer cells (A549). Chem Biol Interact 2007, 165:220?29. 25. Chang CC, Shih JY, Jeng YM, Su JL, Lin BZ, Chen ST, Chau YP, Yang Computer, Kuo ML: Connective tissue growth issue and its function in lung adenocarcinoma invasion and metastasis. J Natl Cancer Inst 2004, 96:364?75. 26. Nakajoh M, Fukushima T, Suzuki T, Yamaya M, Nakayama K, Sekizawa K, Sasaki H: Retinoic acid inhibits elastase-induced injury in human lung epithelial cell lines. Am J Respir Cell Mol Biol 2003, 28:296?04. 27. Kawakami S, Suzuki S, Yamashita F, Hashida M: Induction of apoptosis in A549 human lung cancer cells by all-trans retinoic acid incorporated in DOTAP/cholesterol liposomes. J Control Release 2006, 110:514?21. 28. Zhang H, Rosdahl I: Expression profiles of p53, p21, bax and bcl-2 proteins in all-trans-retinoic acid treated main and metastatic melanoma cells. Int J Oncol 2004, 25:303?08. 29. Wan YJ, Wang L, Wu TC: Detection of retinoic acid receptor mRNA in rat tissues by reverse transcriptase-polymerase chain reaction. J Mol Endocrinol 1992, 9:291?94. 30. Chen N, Napoli JL: All-trans-retinoic acid stimulates translation and induces spine formation in hippocampal neurons by means of a membraneassociated RARalpha. FASEB J 2008, 22:236?45. 31. Tan Y, You H, Wu C, Altomare DA, Testa JR: Appl1 is dispensable for mouse development, and loss of Appl1 has growth factor-selective effects on Akt signaling in murine embryonic fibroblasts. J Biol Chem 2010, 285:6377?389. 32. Saito T, Jones CC, Huang S, Czech MP, Pilch PF: The interaction of Akt with APPL1 is essential for insulin-stimulated Glut4 translocation. J Biol Chem 2007, 282:32280?2287. 33. Mitsuuchi Y, Johnson SW, Sonoda G, Tanno S, Golemis EA, Testa JR: Identification of a chromosome 3p14.three?1.1 gene, APPL, encoding an adaptor molecule that interacts with the oncoprotein-serine/threonine kinase AKT2. Oncogene 1999, 18:4891?898. 34. Hernandez-Cuevas NA, Hernandez-Rivas R, Sosa-Peinado A, Rojo-Dominguez A, Vargas M: Identification and evaluation of inhibitors on the EhGEF1 protein from Entamoeba histolytica. J Mol Recognit 2011, 24:935?44. 35. Ridley AJ, Paterson HF, Johnston CL, Diekmann D, Hall A: The little GTPbinding protein rac regulates development factor-induced membrane ruffling. Cell 1992, 70:401?ten. 36. Arrieta O, Gonzalez-De la Rosa CH, Arechaga-Ocampo E, VillanuevaRodriguez G, Ceron-Lizarraga TL, Martinez-Barrera L, Vazquez-Manriquez ME, Rios-Trejo MA, Alvarez-Avitia MA, Hernandez-Pedro N, Rojas-Marin C, De la Garza J: Randomized phase II trial of All-trans-retinoic acid with chemotherapy primarily based on paclitaxel and cisplatin as first-line remedy in individuals with advanced non-small-cell lung cancer. J Clin Oncol 2010, 28:3463?471. 37. Smith CL, O’Malley BW: Coregulator function: a important to understanding tissue specificity of selective receptor modulators. Endocr Rev 2004, 25:45?1. 38. Robinson SP, Jordan VC: Reversal from the antitumor effects of tamoxifen by progesterone in the 7,12-dimethylbenzanthracene-induce.
