Cle distributed below the terms and situations of your Creative Commons Attribution (CC BY) license ( creativecommons.org/licenses/by/ four.0/).Int. J. Mol. Sci. 2022, 23, 10790. doi.org/10.3390/ijmsmdpi/journal/ijmsInt. J. Mol. Sci. 2022, 23, x FOR PEER REVIEW2 ofInt. J. Mol. Sci. 2022, 23,paper products [14], personal care items [15,16], canned foodstuffs [17], and meals [18]. More than the final decade, BPS use has increased drastically, thereby major to higher envi- 17 two of ronmental exposure to BPS-containing compounds [19,20].Figure 1. Chemical structure of bisphenol S.Figure 1.Additionally, BPS shows a longerS. Chemical structure of bisphenol half-life than BPA and is extra resistant to biodegrada-tion [4]. Hence, BPS is potentially highly persistent and accumulative inside the environment. Additionally, has been detectable half-life than BPA and is matrices, including paper prodRecently, BPSBPS shows a longer in various environmental much more resistant to biodegradation [4]. Thus, BPS is potentially highly persistent and accumulative foods [16,21,22]. ucts, surface water, sewage sediments, sludge, indoor dust, and also some in the atmosphere. Recently, BPS has been detectable in distinct environmental matrices, which includes Thermal receipt paper can also be prospective for occupational exposure to BPS [23]. Furthermore, paper items, surface water, sewage sediments, sludge, indoor dust, as well as somethe the estrogenic activity of BPS is reportedly related to that of BPA [20,24]; on the other hand, foods [16,21,22]. Thermal receipt paper is also prospective for understood. exposure to BPS molecular mechanisms attributed to BPS remain poorly occupational [23]. Also, been connected with asthma and allergic illnesses in each animal and human BPA has the estrogenic activity of BPS is reportedly equivalent to that of BPA [20,24]; nevertheless, the molecular can effect respiratory functionremain poorly understood.GM-CSF Protein Gene ID studies [258]. BPA mechanisms attributed to BPS and trigger airway inflammation in anBPA has been related with asthma and allergic illnesses BPA at animal and huimals [268]. We also reported that the oral intake of low-dose in both levels equivalent to man research [258].can aggravate allergic asthmatic responses result in airway A recent epidemihuman exposure BPA can effect respiratory function and in mice [29]. inflammation in animals [268]. We also that urinary BPS was linked with elevated odds of current ological study reported reported that the oral intake of low-dose BPA at levels equivalent to human exposure can aggravate allergic asthmatic responses in mice [29]. Abisphenol asthma in male adults [30]. Meanwhile, Quir -Alcalshowed that BPS and recent epidemiological study reported that urinaryasthma symptoms or with improved odds of F, but not BPA, have no association with BPS was associated healthcare utilization [31].Genkwanin Anti-infection existing asthma in male BPS was notMeanwhile, Quir -Alcalshowed that BPS and as curIn utero exposure to adults [30].PMID:24013184 also linked with respiratory outcomes such bisphenolasthma and wheeze [32]. Therefore, the with asthma symptoms or healthcare utilizarent F, but not BPA, have no association connection amongst BPS and asthma remains tion [31]. In utero exposure to BPS was not also connected with respiratory outcomes such controversial. In asthma and wheeze [32]. Thus, the oral exposure to low BPS of BPS in a reas current this study, we evaluated the effects ofrelationship betweendoses and asthmamurine model of allergic mains con.
