Le states that choice will have to occur in the moleculargenetic level, not just in the fittest phenotypicorganismic level, to make and clarify life. In other words, MK-4101 site selection for possible biofunction must happen upon formation on the rigid ” phosphodiester bonds in D and R sequences. This can be the point at which functiol linear digital polynucleotide syntax is prescribed. The choice of each nucleotide out of a phase space of four alternatives constitutes the setting of a quaterry (fourway) configurable switch. The particular setting of these switches in nucleic acid key structure (monomeric sequence) determines how translated biopolymer strings will fold into threedimensiol molecular machines.Life,tural choice cannot operate in the genetic level. Choice stress favors only existing biofunction. Even with existing function, tural selection does not pick for isolated function more than nonfunction. The inimate atmosphere couldn’t care less whether or not something functions. The environment has no preferences, values, objectives or desires. Inimate ture is blind and indifferent to utility. This can be even truer of possible utility. Utility can only be defined, appreciated, and pursued formally, not physicodymically. Pragmatics requires an added dimension beyond the four dimensions of Possibility and Necessity. Only the fittest alreadyliving phenotypic organisms are secondarily “selected” by the atmosphere, not abstract conceptual programming at choice nodes, logic gates, and configurable switch settings. tural choice is practically nothing more than the differential survival and differential reproduction with the most effective alreadyliving organisms. For an organism to PubMed ID:http://jpet.aspetjournals.org/content/160/1/171 be alive, it ought to first have a lot of hundreds to thousands of biochemical pathways and cycles already integrated into holistic, cooperative, organized metabolic schemes. Few phenome are far more purposeful and goaloriented than metabolism. Differential survival from the fittest species delivers no model of mechanism for producing the cybernetic programming of linear digital genetic prescription. Biomessages give linear digital guidelines to prescribe cellular structures, distinct transport and catalysis. But D is largely inert from a physichochemical standpoint. tural selection can’t favor unrealized, notyetexistent function represented in D syntax. Life Is Organized, Not SelfOrdered Selfordering phenome will not be examples of Licochalcone-A web selforganization. Selfordering phenome are basic, redundant, and low informatiol. Selfordered structures, no matter if sustained (e.g crystals) or dissipative (e.g the chaos theory initial investigated by Prigogine) contain no organization at all. Selfordering events take place spontaneously day-to-day. But, they don’t involve choice nodes or dymicallyinert, purposeful, configurable switch settings. No logic gates must be programmed with selfordering phenome. Selfordering events involve no steering toward algorithmic success or “computatiol halting”. Selfordering phenome are purely physicodymic and incapable of organizatiol attempts. Laws and fractals are each compression algorithms containing minimal complexity and details. Inimate physicodymics can’t physical exercise purposeful options or pursue possible function. No model of undirected evolution pursues the goal of future utility. Order cannot compute. Significantly lifeorigin literature appeals to “yettobe found laws of selforganization”. Laws, nevertheless, describe highly orderedpatterned behavior. Since they are parsimonious compression alg.Le states that selection will have to occur in the moleculargenetic level, not only in the fittest phenotypicorganismic level, to make and explain life. In other words, choice for potential biofunction ought to occur upon formation with the rigid ” phosphodiester bonds in D and R sequences. That is the point at which functiol linear digital polynucleotide syntax is prescribed. The selection of every nucleotide out of a phase space of four selections constitutes the setting of a quaterry (fourway) configurable switch. The distinct setting of those switches in nucleic acid principal structure (monomeric sequence) determines how translated biopolymer strings will fold into threedimensiol molecular machines.Life,tural choice can’t operate at the genetic level. Selection pressure favors only current biofunction. Even with existing function, tural choice will not pick for isolated function more than nonfunction. The inimate environment couldn’t care less irrespective of whether something functions. The atmosphere has no preferences, values, ambitions or desires. Inimate ture is blind and indifferent to utility. That is even truer of possible utility. Utility can only be defined, appreciated, and pursued formally, not physicodymically. Pragmatics calls for an added dimension beyond the four dimensions of Possibility and Necessity. Only the fittest alreadyliving phenotypic organisms are secondarily “selected” by the atmosphere, not abstract conceptual programming at choice nodes, logic gates, and configurable switch settings. tural selection is practically nothing more than the differential survival and differential reproduction in the most prosperous alreadyliving organisms. For an organism to PubMed ID:http://jpet.aspetjournals.org/content/160/1/171 be alive, it need to 1st have several hundreds to a large number of biochemical pathways and cycles already integrated into holistic, cooperative, organized metabolic schemes. Handful of phenome are additional purposeful and goaloriented than metabolism. Differential survival on the fittest species presents no model of mechanism for creating the cybernetic programming of linear digital genetic prescription. Biomessages supply linear digital guidelines to prescribe cellular structures, particular transport and catalysis. However D is largely inert from a physichochemical standpoint. tural selection can’t favor unrealized, notyetexistent function represented in D syntax. Life Is Organized, Not SelfOrdered Selfordering phenome will not be examples of selforganization. Selfordering phenome are very simple, redundant, and low informatiol. Selfordered structures, whether or not sustained (e.g crystals) or dissipative (e.g the chaos theory initial investigated by Prigogine) contain no organization at all. Selfordering events happen spontaneously everyday. But, they do not involve choice nodes or dymicallyinert, purposeful, configurable switch settings. No logic gates must be programmed with selfordering phenome. Selfordering events involve no steering toward algorithmic success or “computatiol halting”. Selfordering phenome are purely physicodymic and incapable of organizatiol attempts. Laws and fractals are each compression algorithms containing minimal complexity and details. Inimate physicodymics cannot exercising purposeful choices or pursue potential function. No model of undirected evolution pursues the target of future utility. Order cannot compute. Substantially lifeorigin literature appeals to “yettobe found laws of selforganization”. Laws, on the other hand, describe extremely orderedpatterned behavior. Since they are parsimonious compression alg.