.pone.0119985.gAs expected, childhood maltreatment was associated with several SP600125 biological activity covariates known to be related to BMI (Table 3). Some covariates such as unemployment and smoking have been shown in the literature to be negatively associated with BMI, e.g. on average, smokers have a lower BMI [11]. In our study such characteristics were more common among maltreated groups: e.g., prevalence of smoking and unemployment 23y to 50y was ACY-241 manufacturer higher in the maltreated than nonmaltreated (Table 3). Potentially, these differences would lower the adult BMI among those exposed to childhood maltreatment. Allowance for such factors and their changes over time, as well as other covariates, is important for understanding associations with BMI at specific ages and BMI trajectories. Modelled lifetime trajectories of zBMI and obesity risk (Table 4 and S2 Table) confirmed the patterns with age suggested by simple analyses.Childhood abuseIn both genders there was a positive linear association between zBMI gain with age and physical abuse, by 0.006/y (males) and 0.007/y (females) after adjustment for all covariatesPLOS ONE | DOI:10.1371/journal.pone.0119985 March 26,7 /Child Maltreatment and BMI TrajectoriesTable 3. Characteristics of those with no childhood maltreatment and those abused or neglected ( ). Abuse Non-maltreated Males
