: 41.67 ; NS: 183.33 , p 0.05). The The VGB group hadhad fewer rats with SRS
: 41.67 ; NS: 183.33 , p 0.05). The The VGB group hadhad fewer rats with SRS, Figure 2. VGB-treated rats had fewer spontaneous recurrent seizures. (A) (B) VGB-treated group fewer serious seizures Figure 2. above), as in comparison with the spontaneous (stage 3 and VGB-treated rats had fewer(VGB: 41.67 ;recurrent seizures. 0.05). 0.05). (C) Thegroup had fewer severewith SRS, NS group (VGB: 40 ; NS: p (A) The VGB-treated group had fewer rats imply PHA-543613 Epigenetics compared to the standard saline group (VGB: 41.67 ; NS: 183.33 , p p (B) The VGB group count of day-to-day seizures NS: 183.33 , 90 , in comparison to thewas considerably decrease than that for the NS group 0.05). (B) The VGB 6.8 two.62, fewer severeseizures standard saline group had p 0.05) (N = 7 in seizures for the VGB group (VGB: 4.six 1.14; NS: (stage 3 3 and above), as in comparison with the NS group (VGB: 40 ; NS: 90 , p 0.05). (C) The imply count of each day seizures (stage and above), as in comparison to the NS group (VGB: 40 ; NS: 90 , p 0.05). (C) The mean count of everyday seizures for each group). the VGBVGB group was considerably decrease than that the NS group (VGB: 4.6 1.14; NS: 6.86.eight two.62, p 0.05) (N = 7in for the group was significantly reduced than that for for the NS group (VGB: four.six 1.14; NS: two.62, p 0.05) (N = 7 in every single group). every group).three.2. The VGB-Treated Rats Had Significantly less Post-Status Epilepticus Chronic Scaffold Library site Hippocampal Damage3.two. The VGB-Treated Rats the cresyl Post-StatusEpilepticus Chronicthe VGB group had sigAfter VGB-Treated Rats Had Much less violet staining showed that Hippocampal Damage three.two. The epileptogenesis, Had Much less Post-Status Epilepticus Chronic Hippocampal Harm nificantly less neuron loss in the hippocampal CA3 field (see Figure 3A)the VGB NS group Just after epileptogenesis, the cresyl violet staining showed that thethan the group had Soon after epileptogenesis, the cresyl violet staining showed that VGB group had sig(see Figure 3B).lessblind semi-quantitative evaluation showed that the VGB group had sigsignificantly A neuron lossthe the hippocampal CA3 field Figure 3A) than the NS group nificantly significantly less neuron loss in in hippocampal CA3 field (see (see Figure 3A) than the NS nificantly lessFigure 3B). A blind semi-quantitative evaluation showed that the VGB two.1 neuronal damage compared with (VGB: group group (see hippocampalsemi-quantitative analysis showed the NS group group had sig(see Figure 3B). A blind that the VGB 0.three; NS: 2.9 0.4, p much less hippocampal 3C). In conclusion,compared with all the NS group (VGB: had drastically 0.01) (See Figure neuronal harm the VGB-treated group exhibited nificantly much less hippocampal neuronal damage compared using the NS group (VGB: 2.1 significantly less chronic NS: two.9 0.four, damage post-pilocarpine-induced status epilepticus. two.1 0.three; hippocampal p 0.01) (See Figure 3C). In conclusion, the VGB-treated group 0.three; NS: two.9 0.four, p 0.01) (See Figure 3C). In conclusion, the VGB-treated group exhibited exhibited significantly less chronic hippocampal damage post-pilocarpine-induced status epilepticus. less chronic hippocampal harm post-pilocarpine-induced status epilepticus.Figure 3. VGB-treated rats had less post-status epilepticus chronic hippocampal harm. The VGB Figure 3. VGB-treated rats had significantly less post-status epilepticus chronic hippocampal damage. The VGB group (A) had substantially less neuron loss within the hippocampal CA3 area than was the case in group (A) had substantially less neuron loss inside the hippocampal CA3 region than was the case inside the the NS 3. VGB-treated rats had less post-status staining). A chronic hipp.
