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ONCOLOGY LETTERS six: 1140-1146,Composition
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ONCOLOGY LETTERS 6: 1140-1146,Composition and prospective anticancer activities of necessary oils obtained from myrrh and frankincenseYINGLI CHEN1,two, CHUNLAN ZHOU1, ZHENDAN GE1, YUFA LIU3, YUMING LIU4, WEIYI FENG5, SEN LI1, GUOYOU CHEN1 and TAIMING WEI1,College of Pharmacy, Harbin Health-related University-Daqing, Daqing, Heilongjiang 163319; Biopharmaceutical Institute of your Heilongjiang Academy of Healthcare Sciences, Harbin, Heilongjiang 158000; three Department of Chemistry, Chemical Estrogen receptor Agonist medchemexpress Engineering and Material Science, Shandong Normal University, Jinan, Shandong 250000; 4College of Chemistry and Chemical Engineering, Tianjin University of Technologies, Tianjin 300000; 5College of Medicine, Xi’an Jiaotong University, Xi’an, Shanxi 710001, P.R. China Received February 8, 2013; Accepted July 26, 2013 DOI: 10.3892/ol.2013.Abstract. The present study aimed to investigate the composition and possible anticancer activities of important oils obtained from two species, myrrh and frankincense, by hydrodistillation. Employing gas chromatography-mass spectrometry (GC-MS), 76 and 99 components had been identified inside the myrrh and frankincense necessary oils, respectively, with all the most abundant elements, 2-Cyclohexen-1-one, 4-ethynyl-4-hydroxy-3,five,5-trimethyl- and n-Octylacetate, accounting for 12.01 and 34.66 , respectively. The effects with the two important oils, independently and as a mixture, on 5 tumor cell lines, MCF-7, HS-1, HepG2, HeLa and A549, were investigated utilizing the MTT assay. The results indicated that the MCF-7 and HS-1 cell lines showed elevated sensitivity towards the myrrh and frankincense necessary oils compared with the remaining cell lines. In addition, the anticancer effects of myrrh had been markedly improved compared with those of frankincense, however, no substantial synergistic effects have been identified. The flow cytometry results indicated that apoptosis could be a major contributor to the biological efficacy of MCF7 cells. Introduction Commiphora myrrha includes a yellow oleo-gum resin that exists in its stem and is made use of worldwide for the production of myrrh, specifically in China and Egypt. The constituents of myrrh, involve volatile oil (2-8 ), resin (23-40 ), gum (40-60 ) and bitter principles (10-25 ). CDK4 Inhibitor web Preceding research have shown thatmyrrh exhibits cytotoxic, analgesic, antiinflammatory, anticancer, antiparasitic and hypolipidemic activities (1-4). Frankincense is definitely an aromatic resin obtained from trees with the genus Boswellia and has been hypothesized to exhibit numerous wellness supporting properties, which includes the remedy of rheumatoid arthritis and antiinflammatory, antibacterial, antifungal and anticancer activities (5-8). Frankincense oil is ready by the steam distillation of frankincense gum resin and is regularly applied in aromatherapy practices. Based on earlier studies, the constituents of frankincense oil vary in line with the climate, harvest situations and geographical sources from the frankincense resin (9). Notably, these two resinous drugs are generally prescribed simultaneously in regular Chinese medicine and are primarily administered for the treatment of blood stagnation and inflammation ailments, at the same time as for the relief of swelling and discomfort (10). A preceding study identified that the combination of frankincense and myrrh oils exhibited synergistic effects on Cryptococcus neoformans and Pseudomonas aeruginosa (11). The present study investigated the chemical composition of hyd.
