D that PGC-1 mRNA expression was decreased in Old + EXE hearts
D that PGC-1 mRNA expression was lowered in Old + EXE hearts when compared with Old hearts, yet the protein Wnt8b, Mouse (Myc, His-SUMO) content of PGC-1 was comparable. Also, we found that the PPAR mRNA expression was substantially lowered in Old + EXE hearts when compared with Young and Old hearts, however PPAR protein content was significantly higher in Old + EXE hearts compared to Old hearts and similarFrontiers in Physiology | www.frontiersin.orgAugust 2016 | Volume 7 | ArticleBarton et al.Gene Expression Changes Aged HeartTABLE 5 | Exercise-related modifications in gene expression in Old FBN rats. Gene name GLUCOSE METABOLISM Amylo-1,6-glucosidase, 4-alpha-glucanotransferase Aldolase A, fructose-bisphosphate Enolase 1, (alpha) Enolase 2, gamma, neuronal Glucose phosphate isomerase Glycogen synthase kinase 3 alpha Isocitrate UBE2M, Human dehydrogenase three (NAD+) beta Isocitrate dehydrogenase three (NAD), gamma Malate dehydrogenase 2, NAD (mitochondrial) Pyruvate dehydrogenase kinase, isozyme 1 Pyruvate dehydrogenase kinase, isozyme 2 Phosphoglucomutase three Phosphorylase kinase, gamma 1 Ribose 5-phosphate isomerase A Succinate dehydrogenase complex, subunit A, flavoprotein (Fp) Succinate-CoA ligase, ADP-forming, beta subunit Solute carrier loved ones 2 (facilitated glucose transporter), member four FA METABOLISM Acetyl-Coenzyme A acyltransferase 1A Acetyl-Coenzyme A acyltransferase 2 Acyl-Coenzyme A dehydrogenase loved ones, member 10 Acyl-Coenzyme A dehydrogenase family members, member 11 Acyl-Coenzyme A dehydrogenase family, member 9 Acyl-Coenzyme A dehydrogenase, long-chain Acyl-Coenzyme A dehydrogenase, C-4 to C-12 straight chain Acyl-Coenzyme A dehydrogenase, C-2 to C-3 brief chain Acyl-Coenzyme A dehydrogenase, short/branched chain Acyl-Coenzyme A dehydrogenase, extremely lengthy chain Acetyl-coenzyme A acetyltransferase 1 Acetyl-Coenzyme A acetyltransferase 3 Acyl-CoA thioesterase two Acyl-CoA thioesterase three Acyl-CoA thioesterase 7 Acyl-CoA thioesterase eight Acyl-CoA thioesterase 9 Acyl-Coenzyme A oxidase 1, palmitoyl Acyl-Coenzyme A oxidase three, pristanoyl Acyl-CoA synthetase long-chain family member 1 Acyl-CoA synthetase long-chain family members member three Acyl-CoA synthetase long-chain loved ones member four Acyl-CoA synthetase long-chain family member 5 Acyl-CoA synthetase long-chain loved ones member six 3-hydroxybutyrate dehydrogenase, kind 1 3-hydroxybutyrate dehydrogenase, sort two Carnitine palmitoyltransferase 1a, liver Carnitine palmitoyltransferase 1b, muscle Carnitine palmitoyltransferase two Carnitine acetyltransferase Fatty acid binding protein three, muscle and heart Protein kinase, AMP-activated, alpha 1 catalytic subunit Acaa1a Acaa2 Acad10 Acad11 Acad9 Acadl Acadm Acads Acadsb Acadvl Acat1 Acat2 Acot2 Acot3 Acot7 Acot8 Acot9 Acox1 Acox3 Acsl1 Acsl3 Acsl4 Acsl5 Acsl6 Bdh1 Bdh2 Cpt1a Cpt1b Cpt2 Crat Fabp3 Prkaa1 -9.79 -11.7 -7.02 -14.38 -8.81 -21.18 -15.17 -17.09 -7.75 -9.49 -14.79 -6.25 -18.92 -3.52 -4.43 -2.68 -5.41 -5.16 -4.47 -18.06 -3.6 -2.46 -2.23 -5.54 -10.48 -5.03 -3.04 -7.93 -7.02 -4.27 -7.31 1.83 0.001 0.029 0.002 0.002 0.008 0.002 0.009 0.001 0.007 0.002 0.004 0.003 sirtuininhibitor 0.001 0.024 0.027 0.002 0.001 0.007 0.015 sirtuininhibitor 0.001 0.008 0.011 0.001 0.01 0.04 0.008 0.033 0.003 0.004 0.018 0.034 0.042 (Continued) Agl Aldoa Eno1 Eno2 Gpi Gsk3a Idh3b Idh3g Mdh2 Pdk1 Pdk2 Pgm3 Phkg1 Rpia Sdha Sucla2 Slc2a4 -6.15 -5.28 -4.1 -3.27 -5.59 -3.17 -7.7 -5.41 -6.31 -9.29 -6.48 -1.7 -2.78 -2.38 -3.93 -5.64 -10.45 0.024 0.036 0.042 0.019 0.005 0.046 0.04 0.027 0.009 0.004 0.006 0.037 0.011 0.018 0.038 0.021 0.025 Gene symbol Fold Regu.
