Product Name :
Temocapril Hydrochloride
Description:
Temocapril is a prodrug of the ACE inhibitor, temocaprilat (IC50 = 3.6 and 7.6 nM in isolated rat lung and aorta, respectively).1 Upon oral administration it is rapidly deesterified to the active form, which remains long acting until excreted in bile and urine.1 In clinical trials, it has been used to reduce blood pressure, improve endothelial dysfunction, and prevent vascular remodeling, as well as improve insulin sensitivity and renal function in certain hypertensive or diabetic conditions.
CAS:
110221-44-8
Molecular Weight:
513.07
Formula:
C23H29ClN2O5S2
Chemical Name:
2-[(2S,6R)-6-[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino-5-oxo-2-(thiophen-2-yl)-1,4-thiazepan-4-yl]acetic acid hydrochloride
Smiles :
Cl.Tobramycin Antibiotic CCOC(=O)[C@H](CCC1C=CC=CC=1)N[C@H]1CS[C@@H](CN(CC(O)=O)C1=O)C1=CC=CS1
InChiKey:
XDDQNOKKZKHBIX-ASBZXGSUSA-N
InChi :
InChI=1S/C23H28N2O5S2.Itolizumab In stock ClH/c1-2-30-23(29)17(11-10-16-7-4-3-5-8-16)24-18-15-32-20(19-9-6-12-31-19)13-25(22(18)28)14-21(26)27;/h3-9,12,17-18,20,24H,2,10-11,13-15H2,1H3,(H,26,27);1H/t17-,18-,20-;/m0./s1
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥360 days if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
Temocapril is a prodrug of the ACE inhibitor, temocaprilat (IC50 = 3.6 and 7.6 nM in isolated rat lung and aorta, respectively).1 Upon oral administration it is rapidly deesterified to the active form, which remains long acting until excreted in bile and urine.1 In clinical trials, it has been used to reduce blood pressure, improve endothelial dysfunction, and prevent vascular remodeling, as well as improve insulin sensitivity and renal function in certain hypertensive or diabetic conditions.PMID:33090317 |Product information|CAS Number: 110221-44-8|Molecular Weight: 513.07|Formula: C23H29ClN2O5S2|Chemical Name: 2-[(2S,6R)-6-[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino-5-oxo-2-(thiophen-2-yl)-1,4-thiazepan-4-yl]acetic acid hydrochloride|Smiles: Cl.CCOC(=O)[C@H](CCC1C=CC=CC=1)N[C@H]1CS[C@@H](CN(CC(O)=O)C1=O)C1=CC=CS1|InChiKey: XDDQNOKKZKHBIX-ASBZXGSUSA-N|InChi: InChI=1S/C23H28N2O5S2.ClH/c1-2-30-23(29)17(11-10-16-7-4-3-5-8-16)24-18-15-32-20(19-9-6-12-31-19)13-25(22(18)28)14-21(26)27;/h3-9,12,17-18,20,24H,2,10-11,13-15H2,1H3,(H,26,27);1H/t17-,18-,20-;/m0./s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥360 days if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|Products are for research use only. Not for human use.|
