Product Name :
PZ-2891
Description:
PZ-2891 is an orally bioavailable, brain penetrant pantothenate kinase (PANK) modulator. PZ-2891 act as an orthosteric inhibitor at high concentrations and an allosteric activator at lower sub-saturating concentrations. PZ-2891 inhibits human pantothenate kinases PANK1β, PANK2, and PANK3 with IC50s of 40.2 nM, 0.7 nM and 1.3 nM, respectively.
CAS:
2170608-82-7
Molecular Weight:
349.43
Formula:
C20H23N5O
Chemical Name:
6-(4-2-[4-(propan-2-yl)phenyl]acetylpiperazin-1-yl)pyridazine-3-carbonitrile
Smiles :
CC(C)C1=CC=C(CC(=O)N2CCN(CC2)C2C=CC(C#N)=NN=2)C=C1
InChiKey:
LGWDVWIZDPGCFG-UHFFFAOYSA-N
InChi :
InChI=1S/C20H23N5O/c1-15(2)17-5-3-16(4-6-17)13-20(26)25-11-9-24(10-12-25)19-8-7-18(14-21)22-23-19/h3-8,15H,9-13H2,1-2H3
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
PZ-2891 is an orally bioavailable, brain penetrant pantothenate kinase (PANK) modulator. PZ-2891 act as an orthosteric inhibitor at high concentrations and an allosteric activator at lower sub-saturating concentrations. PZ-2891 inhibits human pantothenate kinases PANK1β, PANK2, and PANK3 with IC50s of 40.2 nM, 0.7 nM and 1.3 nM, respectively.|Product information|CAS Number: 2170608-82-7|Molecular Weight: 349.43|Formula: C20H23N5O|Chemical Name: 6-(4-2-[4-(propan-2-yl)phenyl]acetylpiperazin-1-yl)pyridazine-3-carbonitrile|Smiles: CC(C)C1=CC=C(CC(=O)N2CCN(CC2)C2C=CC(C#N)=NN=2)C=C1|InChiKey: LGWDVWIZDPGCFG-UHFFFAOYSA-N|InChi: InChI=1S/C20H23N5O/c1-15(2)17-5-3-16(4-6-17)13-20(26)25-11-9-24(10-12-25)19-8-7-18(14-21)22-23-19/h3-8,15H,9-13H2,1-2H3|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : 75 mg/mL (214.64 mM; Need ultrasonic).|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.Fluvoxamine manufacturer |Shelf Life: ≥12 months if stored properly.Ceftobiprole medchemexpress |Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.PMID:32544974 |Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|PZ-2891 inhibits mouse pantothenate kinases PANK1β, PANK2, and PANK3 with IC50s of 48.7±5.1 nM, 1.0±0.1 nM, and 1.9±0.2 nM, respectively.|References:|Lalit, Kumar, Sharma, et al. A therapeutic approach to pantothenate kinase associated neurodegeneration.[J]. Nature communications, 2018.Products are for research use only. Not for human use.|
